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gh ANTIBIOTICS INTRODUCTION RULES

Kursk , Educational Institution of Higher Professional Education, Kursk State Medical University SCIENTIST: Lubov Siplivaya, Professor
17.10.2008
There are cases when antibiotics are necessary but they can worsen the status of patient. Such situation may be avoided if the drug introduction method is chosen correctly.
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In case of staphylococcosis, ordinary antibiotics injections are ineffective. Specialists of the State-run Educational Institution of Higher Professional Education Kursk State Medical University at the Federal Agency for Public Health and Social Development recommend that the drugs should be introduced on the carriers, the role of which is performed by blood cells. Treatment effectiveness is increased if carrier cells are preliminary processed by ultra-violet rays or in the magnetic field.

Researchers from different countries of the world have been developing for about 20 years the methods for drug introduction based on utilization of cell carriers obtained from formed elements. Erythrocytes and leucocytes of donor blood are used as carriers, which should ensure address delivery of drugs: leucocytes normally migrate into the inflammation focus, and erythrocytes get into the liver and spleen. The Kursk researchers investigated efficiency of ampicillin and cefazolin, included into erythrocytic and leukocytic carriers, in case of staphylococcosis.

As usual, the experiments were made on rats. The animals were intraperitoneally introduced the aurococcus culture, and then were treated by antibiotics. Staphylococcus inhibits the immune system, it is toxic for the liver and causes harmful oxidizing processes. As biochemical analysis has proved, the course consisting of five intramuscular ampicillin and cefazolin injections further increased the negative microbe action. But intravenous injection of antibiotics included into the erythrocytic and leukocytic carriers significantly improved the situation.

Besides antibiotics, there exist other methods for the staphylococcosis treatment. To this end, physicians extensively use the blood irradiated by ultraviolet. After irradiation, the quantity of leucocytes and erythrocytes in the blood increases, and the blood becomes an original biological, which helps well to the patients with pyoinflammatory diseases. Similar action on the blood is also made by staying in the magnetic field of definite intensity. The wish to combine all known treatment methods is quite explainable, and the specialists of the Kursk State Medical University have prepared antibiotics carriers out of erythrocytes and leucocytes which were kept in ultra-violet rays or in the magnetic field. Preliminary processing of carriers has increased the drug action.

In the future, Russian physicians are planning to use the cells of diseased animals, rather than those of donors as containers for antibiotic transportation. As preliminary investigations have proved, activity of antibiotics enclosed in the infected rats cells is sufficiently high, therefore the researchers hope that the donor blood utilization for the staphylococcosis treatment may be minimized.

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